The influence of in vivo treatment of skin with liposomes on the topical absorption of a hydrophilic and a hydrophobic drug in vitro
نویسنده
چکیده
Hairless mice were treated in vivo with empty phospholipid and ‘skin lipid’ liposomes, respectively. The deposition of a hydrophobic drug (hydrocortisone) and a hydrophilic drug (inulin) was investigated in both treated and untreated skin. It was found that drugs should be encapsulated in liposomes or at least be administered together with the lipid, to achieve targeted drug delivery. Pretreatment of the skin with liposomes did not show the advantage of Iiposomally encapsulated drugs.
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